Saturday, April 9, 2011

REGIONAL ANALGESIA

II-REGIONAL ANALGESIA

1-PERINEURAL ANALGESIA
A- Regional analgesia of the head: -
The Horse
1-Infra-Orbital Nerve Block       2-Mental Nerve Block       3-Mandibualr Nerve Block                  4-Supra-Orbital Block         5-Retrobulbar Block         6-Auriculopalpebral Nerve Block
The Ox
1-Cornual Nerve Block                         2-Auriculopalpebral Nerve Block
The Goat
1-Nerve Block For Dehorning
The Dog
1-Infra-Orbital Nerve          2-Mandibular Nerve         3-Auriculpalpebral Nerve Block
B-Regional analgesia of the limbs: -

The Horse
1-Planter Or Volar Nerve Block          2-Median Nerve Block
3-Complete Desensitization Of The Limb Below The Carpus
4-Posterior Tibial And Anterior Tibial (Deep Peroneal) Nerves Block
The Ox
1-Nerve Block In The Forelimb        2-Nerve Block Of The Hind Limb      Method I
                                                                                                                Method II
 The Dog
1-Brachial plexus block                    2-Infiltration of digital nerves
C-Regional analgesia about the trunk

The Horse
1-Analgesia For Castration
The Ox
1-Paravertibral     2-Pudic Or Internal Pudendal     3-Local Analgesia For Castration
The Small Ruminants
1-Paravertibral       2-Pudendal Nerve Block        3-Local Analgesia For Castration
The Dog
1-Paravertibral
2-SPINAL OR EPIDURAL ANALGESIA
A-Caudal epidural analgesia
          The Ox         The Buffaloes          The Horse         The Sheep           The Dog
B-Lumbar epidural analgesia
          The Ox          The Sheep               The Dog
II-REGIONAL ANALGESIA
Advantages: -
1-The amount of used drug is relatively lesser than local infiltration
2-The technique requires no expensive equipments
3-The analgesic area is large enough and there is no need to increase the size of analgesic field during surgery like with local analgesia.
4-Anatomical features of the surgical field don't change as the drug is injected far from surgical field.
5-Healing is not delayed, as the drug is not injected to surgical line.
6-It can be used with or without sedation for surgery on standing animals
Disadvantages: -
1-It is more complicated than local analgesia
2-It has risk of toxicity especially when the nerve is associated with blood vessels
3-General complications of epidural including fracture, infection of neural canal, etc....

1-PERINEURAL ANALGESIA
A- Regional Analgesia Of The Head: -
The Horse
    1-Infra-Orbital Nerve Block: -
Anatomy:
It is the continuation of the maxillary division of the 5th cranial nerve. It passes through the infra-orbital canal (innervates the upper molar teeth, canine, and incisors; and their alveoli and gum), and then it emerges through the infra-orbital foramen (innervates skin of upper lip, cheek, and nostril). After it emerges from the infra orbital foramen, it is partially covered with levator nasolabialis muscle.
Sites of perineural injection:
a-After the nerve emerges from the canal:
The desensitized area will be the skin of the lip, nostril, and face up to the level of the foramen.
b-Within the canal:
This will desensitize the upper molar teeth up to the 3rd, the canine, and the incisors, and their alveoli and gum, and the skin up to the level of the medial canthus of the eye.
c-Within the pterygopalatine fossa:
This will desensitize the molar teeth up to the 6th in addition to the previously mentioned regions.
Indications:
1-Suturing of a wound at the lip or nostril
2-Trephining the facial sinus.
Dose: 5 ml
Technique
a- After the nerve emerges from the canal
The lip of the infra orbital foramen can be felt as bony ridge lying beneath the edge of the flat levator nasolabialis muscle, at a point 5 cm forwards and downwards from the anterior end of facial crest. The needle is introduced until its point can be felt beneath the bony lip of the foramen.
b- Within the canal
The same as mentioned but the needle should pass 2.5 cm up the canal.
c- Within the pterygopalatine fossa
The needle is inserted at a point on the side of the face opposite to the lateral canthus, inferior to the facial crest, and above transverse facial vessels. The needle is advanced medially, slightly anteriorly to pass ventral to the border of zygomatic process and drop into the pterygopalatine fossa just posterior to maxillary tuberosity. The needle should be pushed until it strikes the perpendicular portion of palatine bone in the region of maxillary foramen at a depth of 7 cm. Generally it is a dangerous procedure.
    2-Mental Nerve Block: -
Anatomy:
The alveolar branch of the mandibular division of the 5th cranial nerve enters the mandibular foramen on the medial aspect of the vertical ramus of the mandible under the medial pterygoid muscle. It traverses the mandibular canal and giving off dental and alveolar branches then it emerges from the mental foramen and called mental nerve. The innervation of the incisors and canines arises from the trunk nerve 3-5 cm before it emerges from the mental foramen.
Technique:
The mental foramen, through which the mental nerve emerges, lies on the lateral aspect of the ramus in the middle of the inter-dental space and covered with the tendon of depressor labii inferioris muscle. Injection of the nerve at this point desensitizes the lower lip only, while advancing the needle 3-5 cm into the canal will desensitize the incisors and canine too.
Indication:
Suturing of wounds of the lower lip
    3-Mandibualr Nerve Block: -
Technique:
The mandibular nerve is injected at its point of entry into the mandibular canal at the mandibular foramen. The mandibular foramen lies opposite to the point of intersection of a line passes vertically downwards from the lateral canthus and a line extending backwards from tables of mandibular molar teeth. This nerve can be blocked by two methods.
1-The needle is inserted into a point 3 cm below the temporomandibular joint between the wing of the atlas and base of ear. Then the needle is advanced towards the point of intersection of the mentioned lines, medial to the medial surface of the mandible.
2-The needle is inserted directly in front of the angle of the mandible, medial to the medial surface of the mandible, towards the mentioned point. The needle should be inserted 12 cm forwards at least.
Dose:
5 ml lidocaine HCl 2%
    4-Supra-Orbital Block: -
Anatomy:
Supra-orbital or frontal nerve is a branch of ophthalmic division of 5th cranial nerve, emerges from the orbit through the supra-orbital foramen in the supra-orbital process.  It innervates the upper eyelid and skin of the fore head.
Technique:
The upper and lower borders of the supra-orbital process, close to its junction to the frontal bone, are palpated, and the foramen is detected midway between the two borders, then the needle is inserted into the foramen and the nerve is blocked.
Dose:
5 ml lidocaine HCl 2%
Indication:
Operations of the upper eyelid or suturing of wounds
    5-Retrobulbar Block: -
It is a technique used for blocking of nerves behind the eye ball.
Technique:
1-The needle is inserted 1.5 cm behind the middle of the supra-orbital process and pushed towards the upper molar teeth of the opposite side.
2-The needle is inserted in the angle between the temporal process of zygomatic bone and the supra-orbital process and is advanced towards the base of the orbit (modified Peterson technique).
3-The needle is inserted into 4 sites at 3, 6, 9, and 12 O'clock.
Dose:
20-30 ml lidocaine HCl 2%
Indications:
Analgesia and akinesia of periocular muscles for enucleation of the eyeball. The large amount of injected drugs creates state of exophthalmos to facilitate enucleation.
    6-Auriculopalpebral Nerve Block: -
As ox
The Ox
    1-Cornual Nerve Block: -
Anatomy:
It is a branch of the superior maxillary division of 5th cranial nerve that innervates the corium and the skin of the horn. It emerges from the orbit and ascends behind the lateral ridge of the frontal bone.
Technique:
The nerve is injected at the upper 3rd of the frontal ridge, just behind the ridge, 2.5 cm below the base of the horn, as it is superficial at this region and covered with thin layer of frontalis muscle. The needle shouldn't be inserted so deep to avoid injection under the aponeurosis of temporal muscle. Another injection 1 cm behind the original site can be done to ensure blocking of the posterior division.
Dose:
*5 ml Lidocaine HCl 2%
Indication:
Dehorning, or surgical intervention of either fractured horn or horn separation
    2-Auriculopalpebral Nerve Block: -
Anatomy:
It is a motor nerve of orbicularis oculi muscle, runs from the base of the ear along the facial crest.
Technique:
The needle is inserted rostoral to the base of the ear at the summit of zygomatic arch or its dorsal border. 
Dose:
*5-10 ml Lidocaine HCl 2%.
Indication:
Induction of paralysis (akinesia) of the eyelids for eye examination, surgical interferences of the eyeball, or removal of foreign bodies from the cornea or conjunctive (in conjunction with topical analgesia of the cornea)
The Goat
    1-Nerve Block For Dehorning: -
Anatomy:
The cornual branch of the lacrimal nerve emerges from the orbit behind the root of the supra-orbital process covered by thin layer of frontalis muscle and innervates the caudolateral aspect of the horn, while infra-trochlear nerve emerges from the orbit dorsomedially and divided into dorsal corneal branch that innervates the dorsomedial aspect of the horn, and medial frontal branch that innervates the caudomedial aspect of the horn, and both nerves are covered with orbicularis muscle at the lower part and with frontalis muscle at the dorsal part.
Technique:
The corneal branch of lacrimal nerve is injected close to caudal ridge of the root of the supra-orbital process.
The corneal branch of the infra-trochlear nerve is injected at the dorsomedial margin of the orbit, 0.5 cm deep.
Dose:
*3 ml lidocaine HCl 2%
Indication:
Dehorning, or surgical intervention for treatment of fractured horn or horn separation
The Dog
This technique of dental nerve block is no longer be used in dogs as a result of the development of technique of general anesthesia in this species, and when it is used, it is combined with sedatives.
    1-Infra-Orbital Nerve: -
Anatomy:
The maxillary nerve derived from the 5th cranial nerve, that emerges from the cranium through foramen rotundum, passes forwards in the pterygopalatine fossa, and continued in the infra-orbital canal as infra-orbital nerve.
-The 1st and 2nd molar teeth are innervated by small branches derived from the main trunk before it inters the canal.
-The 4 premolars and their alveoli and gum are innervated by filaments derived from the nerve as it passes through the canal.
-The nerve supply to canines and incisors is given off in the canal and passes forwards in the maxillary and premaxillary bones.
Technique:
a-In the pterygopalatine fossa at its point of entry to desensitize the whole teeth in the upper jaw in that side. A point 4 cm below the lateral canthus in the space between the posterior border of malar bone and anterior border of coronoid process of the mandible is detected. The needle is inserted in this area and advanced in the soft tissue until its point passes the egde of malar bone. Then it is redirected forwards towards the maxillary foramen 3 cm from the point of insertion. The technique is difficult and may have risk.
b-In the lower part of the infra-orbital canal through infra-orbital foramen for desensitization of incisors, canines, and first two premolars. This technique is made through the gum over the 3rd premolar tooth at line of reflection of mucous membrane of cheek under which the lip of the infra-orbital foramen can be detected. The needle should be advanced 1 cm in the canal. The technique is easy but the area of desensitization is small.
Dose:
*Procaine HCl 2% 2 ml for point (a) and 1 ml for point (b).
    2-Mandibular Nerve: -
It is derived from 5th cranial nerve, passes downwards deep to the medial pterygoid muscle and inters the mandibular canal at the mandibular foramen on the medial aspect of the ramus.
-Molar and premolar teeth are innervated by fibers derived from the main trunk while it stills inside the canal.
-The canines and incisors are innervated by branch derived from the main trunk and passes forwards within the ramus.
Technique:
a-On the medial aspect of the ramus at the mandibular foramen, that will desensitize all teeth of the lower jaw on that side. The needle is inserted at the middle of the depression on the posterior part of the ventral border of the ramus, in a right angle to the ventral border of the jaw, close to the medial aspect of the bone, and advanced for 2 cm to reach the mandibular foramen. The technique is difficult to be performed.
b-In the anterior part of the mandibular canal through the mental foramen, that will desensitize lower incisors, canines, and first two premolars on that side. The mental foramen is injected through the gum immediately beneath the anterior root of the 2nd premolar tooth, and the needle should be advanced 0.7 cm in the canal. The technique is easy but the area of desensitization is small.
Dose:
*Procaine HCl 2% 2 ml for (a) and 1 ml for (b).
    3-Auriculpalpebral Nerve Block: -
Anatomy:
The nerve runs caudal to mandibular joint at the base of the ear, gives the anterior auricular nerve and then proceeds as temporal branch along the upper border of zygomatic arch towards the orbit, and finally near the orbit it divides into medial and lateral branches to innervate the orbicularis oculi muscle.
Technique:
Point of needle insertion is the midpoint of posterior 3rd of zygomatic arch.
Dose:
*Procaine HCl 2% 1 ml
Indication:
The nerve is motor nerve and its blocking has clinical value for facilitating eye examination, eye operations, and prevention of blinking and squeezing of the eye after intra-ocular surgery.
B-Regional Analgesia Of The Limbs: -

The Horse
    1-Planter Or Volar Nerve Block: -
Anatomy:
-In the forelimb, the medial high volar nerve passes with the artery and vein (VAN) in the groove between the suspensory ligament and digital flexor tendons. At the middle of the cannon bone, the medial nerve sends branch to the lateral high volar, that passes behind the flexor tendons and join the lateral branch at the level of the button of splint bone. At the fetlock region, every volar nerve divides into three branches named low volar nerves and pass in the same relation to the artery and vein (VAN) but the artery sinks slightly. The anterior branch innervates coronary cushion; the middle branch innervates coronary cushion and sensitive laminae, and the posterior digital branch innervates sensitive laminae and os pedis.
-In the hind limb, planter nerves are the continuation of posterior tibial nerve. They have the same anatomical position like the forelimb, but their clinical significance is lower than that of the forelimb, because the digit is innervated by branches from the anterior tibial nerve (deep peroneal).
Technique for high volar block:
The site of injection is 7 cm above fetlock, in the groove between suspensory ligament and flexor tendons. The needle is inserted with an angle of 15° with the vertical line and directed downward and inward.
Dose:
*5 ml lidocaine HCl 2%
Indication:
Desensitization of the limb from the fetlock and downward, including pastern and coffen joints for;
1-Diagnosis of lameness of affected limb and opposite one                             2-Relieve of pain
3-Operative procedures
a-Neurectomy
b-Operative procedures at the foot, coronet, or heel, like exposure of corn, or removal of nail, partial operation of quitter or sandcrack
Technique for low volar block (posterior digital):
The needle is inserted at the midway between fetlock and coronet in the groove between the 1st phalanx and the flexor tendon with an angle of 15° with the vertical line and directed downward and inward.
Dose:
*2-4 ml Lidocaine HCl 2%
Indication:
Sensation remains in the anterior and lateral parts of the foot, so it is used mainly for diagnosis of navicualr disease.
    2-Median Nerve Block: -
Anatomy:
The nerve lies 5 cm below the elbow joint in the groove between the posterior border of the radius and the flexor carpi radialis, deep to the posterior superficial pectoral muscle, hand fist above the chest nut.
Technique:
The needle is inserted in the mentioned site and advanced inward and upward with an angle 20° with the vertical line
Dose:
*10 ml Lidocaine HCl 2%
Indication:
Median nerve neurectomy, as the desensitized area is little more than that obtained by medial high volar block.
    3-Complete Desensitization Of The Limb Below The Carpus: -
Anatomy:
For complete desensitization of the limb below the carpus, three nerves should be blocked. Theses three nerves are the median, ulnar, and musculocutaneous nerves. Ulnar nerve can be located 7 cm above the carpus in the groove between the ulnaris lateralis and flexor carpi ulnaris, while musculocutaneous nerve lies at the medial aspect of the limb on the surface of the radius half way between the elbow and the carpus in front of cephalic vein.
Technique:
The needle is inserted in the mentioned sites
Dose:
*10 ml Lidocaine HCl 2% for each nerve
Indication:
Any surgical interference below the carpus
    4-Posterior Tibial And Anterior Tibial (Deep Peroneal) Nerves Block: -
Anatomy:
The posterior tibial nerve lies 15 cm above the point of the hock in the space between Achilles tendon and long digital flexor. The nerve becomes closer to the Achilles tendon as the limb is flexed. While the anterior tibial nerve lies in the groove between tendons of long and lateral extensors above the lateral malleolus.
Technique:
The needle is inserted in the mentioned sites
Dose:
20 ml lidocaine HCl 2% for posterior tibial and 10 ml for anterior tibial nerve
Indication:
Desensitization of the posterior aspect of metatarsus, the medial and lateral aspects of the fetlock, and the whole digit. For complete desensitization down the hock, the saphenous, superficial peroneal, and posterior cutaneous nerves should be blocked.
The Ox
    1-Nerve Block In The Forelimb: -
Nerve supply of the digits of the ox is much more complex than the horse. For complete analgesia of the digits, five points (1, 2, 3, 4 & 5) should be blocked. For analgesia of the medial digit, points (1, 4 & 5) should be injected with analgesic. While for complete analgesia of the lateral digit points (1, 2, 3 & 4) should be blocked.
1-Dorsal metacarpal nerve (Radial) at the middle of metacarpal medial to extensor tendon.
2-The dorsal branch of ulnar nerve about 5 cm above the fetlock on the lateral aspect in the groove between suspensory ligament and metacarpal bone.
3-The volar branch of ulnar nerve about 5 cm above the fetlock, and caudal to the suspensory ligament at the same level of dorsal ulnar nerve.
4-The lateral branch of the median nerve and small branch of the ulnar nerve can be injected at the midline just above the fetlock on the caudal aspect of the limb.
5-The medial branch of the median nerve can be injected in the grove between suspensory ligament and flexor tendon on the medial aspect.
However the technique is not easy and missing of one nerve block requires re-blocking of all the sites again, so it is preferred to make ring block rather than perineural injection for surgical interference at the digits.
    2-Nerve Block In The Hind Limb: -
Method I: -
The tibial and external popliteal (common peroneal) are blocked above the hock and they produce complete loss of sensation down the fetlock.
Advantages:
1-Only two injections are necessary.
2-Injection to soft tissue and at convenient level permits easy application with thin needle, during standing with minimal restraint.
3-The nerves can be located by clear landmarks.
4-There is moderate interference with the motor function of the limb.
5-Most of the lower limb rendered analgesic.
6-It avoids complications of injection at the diseased tissue of the digit.
Technique:
1-The common peroneal nerve (external popliteal) can be blocked behind the posterior edge of the lateral condoyle of the tibia, over the fibula and before it dips down between the extensor pedis and flexor metatarsi muscles, for giving off superficial and deep peroneal nerves.
2-The tibial nerve can be blocked 10 cm above the summit of os calcis on the medial aspect of the limb anterior to Achilles tendon.
Dose:
1-The common peroneal nerve is blocked with 20 ml Lidocaine HCl 2%
2-The tibial nerve is blocked with 20 ml Lidocaine HCl 2%
Method II: -
Technique:
1-The superficial peroneal is blocked in the upper 3rd of metatarsus subcutaneously over the dorsal aspect of the metatarsus.
2-The deep peroneal nerve can be located halfway down the metatarsus in a groove on the dorsal aspect and covered with extensor tendons.
3-The planter metatarsus nerves can be blocked on both sides like high volar in horse.
Dose:
*5 ml Lidocaine HCl 2% for each nerve of the mentioned 4 nerves
The Dog
    1-Brachial plexus block: -
It is a simple method for induction of analgesia of the forelimb, and it causes analgesia and relaxation from the elbow joint and downwards.
Technique:
With the animal standing, the depression at the center of the triangular area (bounded by the anterior border of supraspinatus muscle, the chest wall, and the dorsal border of brachiocephalicus muscle) is detected. The head is held away, and the 7.5 cm long needle is inserted into of that depression after locating the 1st rib. The needle is guided backwards lateral to the chest wall and medial to subscapularis muscle until its point is judged to be at the level of scapular spine.
Dose:
Lidocaine HCl 2% 2 ml
Complications:
1-Hematoma.                                          2-Acedintal intravenous injection of the drug
3-Damage and neuritis of the plexus     4-Penetration of the thorax       5-Infection of the axilla
    2-Infiltration of digital nerves: -
These nerves are injected subcutaneously, medial and lateral to the 1st phalanx of each digit, with 2 ml lidocaine HCl 2%.
C-Regional Analgesia About The Trunk: -

The Horse
    1-Analgesia For Castration: -
Local infiltration of the scrotum and direct injection of up to 20 ml lidocaine HCl 2% into the testicle itself
The Ox
    1-Paravertibral Block: -
It is a perineural injection of spinal nerves as they emerge from the vertebral canal through the inter-vertebral foramina. It can be used for induction of laparotomy (rumenotomy or caesarian). The last thoracic and the 1st and 2nd lumbar nerves can be blocked for induction of rumentomy, while the 1st three lumbar nerves should be blocked for caesarian section in the flank region.
Advantages:
1-Complete and uniform desensitization of the abdominal wall and peritoneum
2-Relaxation of the abdominal muscles with reduction of intra-abdominal pressure
3-Short post-surgical convalescence period     4-Lower amount of local analgesia can be used.
5-It over comes the disadvantages of inverted-L block and linear infiltration
Technique:
1-The last thoracic can be blocked 5 cm from the midline caudal to the head of the last rib and 5 cm deep.
2-The lumbar nerves can be blocked by insertion of the needle 5 cm far from the midline on a level with a line drawn just behind the spinous process of particular vertebra.
Dose:
*20 ml Lidocaine HCl 2% for each nerve (15 ml below the inter-transverse ligament and 5 ml above it)
    2-Pudic Or Internal Pudendal Block: -
This nerve is blocked for induction of protrusion of the penis by a method other than epidural analgesia to avoid the disadvantages of epidural in large or heavy bulls.
Technique:
1-After location of the nerve per rectum, in the sacrosciatic foramen, the needle is introduced via the ischiorectal fossa medial to the sacroisciatic ligament, and is directed forwards and downwards for 7 cm.
Dose:
*30-40 ml Lidocaine HCl 2% (20-25 at the mentioned site and 10-15 slightly behind)
Disadvantages:
1-The success rate of this technique is 66%.
2-The onset can be delayed as late as 30-45 minutes.
3-Some bulls may show protrusion of the penis as long as 24 hours post injection.
    3-Local Analgesia For Castration: -
1-The site of the proposed incision in the scrotum may be rendered analgesic by local or subcutaneous infiltration, however this will not block the nerve fibers in the spermatic cord. Accordingly, these fibers can be rendered analgesic by;
2-Direct injection of 10 ml Lidocaine HCl 2% into each cord at the neck of the scrotum.
3-Direct injection of 5-25 ml Lidocaine HCl 2% into the testicle itself. Accordingly the drug will pass through the lymph, diffuses, and blocks the fibers in the spermatic cord.
For bloodless castration, both local infiltration at the scrotal neck and direct injection into the spermatic cord should be used.
The Small Ruminants
    1-Paravertibral Block: -
It can be performed as with cattle, and each nerve is blocked by 7 ml lidocaine HCl 1% (5 ml below the inter-transverse ligament and 2 ml above it).
    2-Pudendal Nerve Block: -
Anatomy:
The anterior tuberosity of tuber ischii is used as fixed point, and the length of sacro-tuberous ligament is sued as a radius. This distance is used to establish a site on a line parallel to the midline in front of the fixed point. A finger is introduced through the rectum for detection of the lesser sciatic foramen, and the needle is inserted at the previously mentioned point. The penis will protrude 5 minutes post injection.
Dose:
7 ml lidocaine HCl 2%
    3-Local Analgesia For Castration: -
1-Direct injection of 2-10 ml lidocaine HCl 1% into the testicle itself, followed by local subcutaneous infiltration at the line of incision.
2-Other methods mentioned in cattle.
The Dog
    1-Paravertibral Block: -
The last three thoracic and the 1st four lumbar nerves should be blocked to produce analgesia and relaxation of abdominal muscles; accordingly it can be sued with light general anesthesia. This technique can be used bilaterally to induce complete relaxation of abdominal muscles, however, disadvantage of this technique is time consuming, and its advantage is there is no need for muscle relaxant and artificial ventilation.
Dose:
Lignocaine HCl 1 % 2 ml
2-SPINAL OR EPIDURAL ANALGESIA

A-Caudal Epidural: -
The Ox
It is a process through which the analgesic solution is injected between the two layers of dura matter and affects the terminal nerves or cauda equina thus producing analgesia of the posterior half of the animal. The term anterior and posterior epidural analgesia is related to the dose of injected analgesic solution and not to the site of injection.
    1-Posterior epidural characterized by no affection of the motor function of the hind limbs, but analgesia or loss of sensation can be observed over the tail, croup as far as the mid-sacral region, the anus, vulva, perineum, and posterior aspect of the thighs. Paralysis of motor fibers predisposes to relaxation of anal sphincter and ballooning of posterior part of the rectum. Defecation will be suspended and stretching of the vulva provokes no response. The vagina will dilate and straining, during parturition, ceases without affecting uterine contraction.
    2-Anterior epidural shows some degree of interference with motor function of the hind limbs. This will vary from partial paralysis of stifle flexors, and flexors and extensors of hocks and digital joints, to complete paralysis. In coordination may predispose to injury to the animal or the workers. Loss of sensation spreads forwards, according to the dose; over the croup; between hind limbs till the inguinal region, scrotum, and prepuce; over the hind limbs; mammary gland; and finally flanks and abdominal wall till the umbilicus. As the drug blocks the sympathetic outflow of the thoracic and lumbar segments, hypotension will occur and the normal compensatory mechanism (tachycardia) will be affected as the cardiac accelerator nerves will be blocked so the heart rate will not be increased to compensate the hypotension. This hypotension has the advantage of lowering the chance of bleeding during surgery but on the other hand, minimal loss of blood threatens the animal life.
Seat of injection:
The first intercoccygeal space between the 1st and 2nd coccygeal vertebra. Its dimensions are 2 cm transversely, 2.5 cm anterior-posteriorly, and 0.5 cm deep. The canal is 2-4 cm deep from the skin surface.
Technique:
The needle is inserted with 15° degrees with the vertical. When the needle reaches the accurate site, there will be no resistance for injection, and suction of the drug from the hub of the needle can be seen.
1-The tail is gripped 15 cm from its base and raised in pump-handle fashion. Seat of injection is the 1st obvious articulation behind the sacrum.
2-Stand beside the animal and detect the 1st prominence after the croup (prominence of the sacrum), seat of injection is the depression directly behind this prominence.
3-A line has drawn directly over the back connecting two points (one on each side) 10 cm anterior to posterior prominence of the ischeal tuberosity. Seat of injection is the point of intersection between this line and midline.
Dose:
1-Caudal block:
a-Procaine HCl
*15-20 ml 1%.
*10-15 ml 2%.
*5-10 ml 3-5%.
b-Lignocaine HCl or lidocaine HCl
5-10 ml 2%
2-Anterior block:
a-Procaine HCl
*40 ml 3% (mastectomy)
*170 ml 1% or 120 ml 1.5% (amputation of the digit)
*45 ml 2% (caesarean)
b-Tutocaine 1%
*60-100 ml (difficult obstetrical interferences)

*120 ml (caesarean)
Onset and duration:
a-Caudal block:
Paralysis of the tail can be observed after 1-2 minutes, the maximal effect appears after 10-20 minutes, and lasts for 60 minutes, and the animal becomes normal again by the end of 120 minutes.
b-Anterior block:
Paralysis of the tail can be observed after 1-2 minutes, the maximal effect appears after 10-20 minutes, and the animal will be unable to rise for 120 minutes, and in coordination may persist for 3-4 hours
Indications:
1-Caudal block:
a-Obstetrics:
1-To overcome straining for correction of malpresentation, or for simpler embryotomy
2-Operative treatment of parturient injuries  3-Reduction of prolapsed uterus or vagina
b-General:
1-Surgical operations of the tail                  2-Surgical correction of tears of vulva or perineum
3-Examination of the vagina or external cervical os                            4-Protrusion of the penis
2-Anterior block:
a-Obstetrics:
1-To overcome straining during extensive embryotomy
2-Amputation of gangrenous prolapsed uterus                                  3-Caesarian section
b-General:
1-Surgery of penis                    2-Cutting operations about the prepuce or inguinal region
3-Amputation of the udder       4-Castration      5-Surgery of hind limb like amputation of digit
Disadvantages:
1-Infection of the nervous system
2-Fracture of the animal pelvis, and injury to workers, or veterinarian (anterior block)
3-Hypovolumic shock due to involvement of vasomotor nerve fibers and pooling of blood in the venous side with absence of compensatory tachycardia (anterior block)
4-Asphyxia due to paralysis of phrenic nerve
5-Twisting of the tail few days or even permanent paralysis after injection due to injury of nerve fibers innervate the tail
The Buffaloes
The needle is inserted downwards and forwards in the sacrococcygeal with an angle 45º with the vertical.
The Horse
The technique is not common in equine as in bovine because the indications for such technique in equine are not frequent and the detection of site of injection is more difficult.
Seat of injection:
1st intercoccygeal space in horse and 2nd intercoccygeal space in donkey. The depth of the canal is 4-8 cm.
Technique:
The needle is inserted forwards and downwards with an angle of 30° degrees with the horizontal (60° with the vertical).
1-A line drawn connecting the hip joints and intersects the midline at the level of the sacrococcygeal joint caudal to which the dorsal spine of the 1st coccygeal bone can be felt. The needle inserted into the depression directly caudal to this point.
2-The space is opposite the caudal fold formed on each side of the tail when raised.
Indications:
1-Caudal block:
a-Obstetrics:
1-To overcome straining during manipulative correction of simpler forms of malpresentation 2-Partial embryotomy
b-General:
1-Amputation of the tail                                   2-Operations about the anus, perineum, or vulva
3-Operation for rectal prolapse                          4-Caslick operation for windsucking
2-Anterior block:
a-Obstetrics:
Obstetrical difficult manipulative repositions and extensive embryotomy
b-General:
Scrotal hernia and cryptorchidism
Dose:
1-Caudal block:
a-Procaine HCl 2%
*5-15 ml (amputation of the tail)
*10-25 ml (perineal and vulvar operation)
*15-30 ml (obstetric manipulation)
b-Lignocaine HCl or lidocaine HCl
*10 ml 2%
2-Anterior block:
a-Procaine HCl
*50-120 ml 1% (severe obstetrical interferences)
*30-80 ml 2% (cutting operation)
b-Lignocaine HCl or lidocaine HCl
*100-150 ml 2% (analgesia of hind limbs to the costal arch)
The Sheep
Seat of injection:
Sacrococcygeal space
Dose:
*3-4 ml 2% lignocaine HCl (intravaginal obstetrical procedures)
*1 ml 5% procaine HCl (docking of lambs)
Indications:
1-Intravaginal obstetrical procedures
2-Relief of painful conditions of vagina and rectum that provoke severe straining
The Dog
Seat of injection:
Sacrococcygeal or 1st intercoccygeal space
Dose:
*1 ml 2% lignocaine HCl
Indications:
1-Docking of tail
B-Lumbar Epidural Analgesia: -
Injection of analgesic solution into the epidural space in the caudal region (caudal epidural) affords very save method of inducing epidural analgesia, but sometimes it is not easy to produce satisfactory anterior block via this site. The lumbar epidural analgesia through the anterior lumbar region or lumbosacral spaces, affords a belt of analgesia around the trunk of the animal without affecting the motor function of the hind limbs.
The Ox
Seat of injection:
Seat of injection is just to the right of the lumbar spinous process of the 2nd lumbar vertebra, 1.5 cm caudal to the anterior edge of the second lumbar transverse process.
Dose:
* 10-15 ml Tutocaine 2%
* 10 ml Procaine HCL 4% (15 ml weakens the hind limbs- 20 ml the animal lie down)
*8 ml Lignocaine 3%
*10 ml Lignocaine 2%
Indications:
This technique is used for induction of flank analgesia for rumenotomy or caesarian.
The Sheep
Seat of injection:
Lumbosacral space to avoid puncturing of meninges. It is located just behind the spinous process of last lumbar vertebra that lies at a point of intersection between line drawn to connect the anterior borders of the two illiums and midline.
Technique:
The needle is inserted in the mentioned space with an angle 10° anterior and 15° lateral with the vertical.
Dose:
8-15 ml Lignocaine 3%
Indication:
Intra-abdominal, pelvic, or hind limb surgery
The Dog
Seat and technique:
Lumbosacral space as sheep
Dose:
0.5 ml/Kg
Indications:
1-Posterior abdominal (hysterectomy, or cystotomy) or inguinal surgery
2-Treatment of hind limb fracture






LOCAL ANALGESIA

I-LOCAL ANALGESIA
Many surgical procedures can be satisfactorily performed under the effect of local analgesia alone, and the use of sedation with this technique depends up on the species, temperament, and health of the animal, and magnitude of the operation. Sedation should be avoided in surgical procedures when the animal should not lie down, otherwise sedation should be adopted when reduction of fear and liability of sudden movement is required for achievement of efficient surgery. Moreover, the dose of sedative drug must be reduced on using certain types of local analgesics like lignocaine as it has systemic sedative effect following its absorption.   
Advantages: -
1-It is suitable for performing surgery on standing animals, accordingly injuries associating casting and prolonged recumbency can be avoided
2-The technique is simple and requires no expensive or complicated equipments
3-The technique can be performed by the surgeon himself with no need for anesthetist
Disadvantages: -
1-Injection shouldn't be performed in infected area to avoid spreading of infection
2-Direct injection of the drug at seat of incision causes delay of healing as a result of histotoxic effect of the drug
3-The amount of used local analgesic drug is relatively higher than other methods like perineural analgesia, accordingly the cost increases
LOCAL ANALGESICS: -
Desirable characteristics of local analgesic agents: -
1-It should has good penetrating qualities through body tissues                       
2-It should has rapid onset
3-It should be potent so that low concentrations can be used    
4-It should has long duration of action
5-It should has low systemic toxicity                   
6-It shouldn't be irritant to nerve and other body tissues
7-It should has reversible action      
8-It should be available in sterile solution or it can be easily sterilized
Potentiation by vasoconstriction: -
Addition of vasoconstrictor (epinephrine) to local analgesic, at concentration of 1:200,000 allows prolonged analgesic effect by vasoconstriction and delaying absorption of the drug. The maximum safe concentration of epinephrine is 1:50,000 but greater concentrations may cause local tissue ischemia and necrosis, accordingly these agents shouldn't be used in extremities, tail, or teat, etc...to avoid the possibility of ischemia and subsequent necrosis and gangrene. The exception to this rule is the epidural analgesia where concentration up to 1:10,000 may be safely used. Generally the used of analgesic agents that contain vasoconstrictor is contra-indicated in injured tissue as this tissue might be already ischemic and the further injection with epinephrine may deteriorate the condition of the ischemic tissue and causes gangrene.
Potentiation by hyaluronidase: -
Hyaluronidase is a mucolytic enzyme that hydrolyses hyaluronic acid that is known as the ground substance preventing diffusion of drug in the tissues. Incorporation of that chemical substance in the analgesic solution facilitates diffusion and penetration of the analgesic drug into the tissue and accordingly the drug will acquire faster on set.  
Advantages: -
1-It promotes diffusion and absorption of the local analgesic with which it is mixed
2-It is of particular value in nerve block, especially if the analgesic didn't deposited accurately around the nerve
Disadvantages: -
1-Toxicity although the ratio of toxic to therapeutic dose is 200:1
2-Reduction of analgesia duration
3-Increased toxicity by analgesic drug itself as a result of rapid absorption
Generally, the last two disadvantages can be counteracted by addition of epinephrine to the solution
AVAILABLE LOCAL ANALGESICS: -
A-Minor local Analgesics: -
1-Ethyl Chloride:
-It is a topical local analgesic, marketed under pressure in containers with a fine capillary nozzle and a control valve that allows the liquid to be sprayed.
-It has a very superficial and transient analgesic action, and when it is sprayed on the skin, it evaporates leading to freezing of the skin with induction of surface analgesia for 30-60 seconds.
-Its use is limited to simple incisions or punctures such as incision of abscess or hematoma.
2-Ethyl alcohol: -
-Injection of absolute alcohol around a nerve produces neuritis, degeneration, and sclerosis, however, 30% alcohol temporarily destroys sensory nerves that regenerate again after a variable period, and nerve function will return by then. Duration of block depends on;
1-The size of the nerve                    
2-Degree of destruction
-Small-unsheathed nerves may be permanently destroyed, whereas, large heavily sheathed nerves are only temporarily affected.
B-Major local Analgesics: -
Cocaine was the first available local analgesic, but its toxic effect and addictive properties in human restricted its use and availability. Nodaway, many new generations of local analgesics are available, and they vary according to their potency, toxicity and cost. The present three categories are classified according to duration of analgesic action
Analgesia duration
Drug
Duration
1Short Procaine30-60 minutes
2Intermediate Lidocaine and mepivacaine90-180 minutes
3Long Tetracaine and bupivacaine180-300 minutes
1-Short duration analgesic: -
Procaine HCl: -
Procaine HCl is a white, crystalline, water-soluble powder
Advantages: -
1-Its subcutaneous injection has an efficiency approximating that of cocaine, but it has lower toxicity especially when adrenaline HCl is added (10 times less toxic)
2-It is non-irritant
3-Relatively stable solution
4-It can be sterilized repeatedly by boiling without loss of potency
5-It is rapidly and completely detoxicated by the liver when absorbed slowly from injection site (ensured by adding adrenaline), so that a second infiltration can be carried out in the course of an hour
Disadvantages: -
1-Toxic when accidentally injected intravenous
2-It has low power of penetration
3-It can not be used for topical application or intra-synovial analgesia as it has very low power of penetration of mucous membrane
4-Decomposed by alkali
Concentration, on set, and duration: -
Use
Concentration
On set
Duration
General skin or gum infiltration  in pets2 %5 minutes
1 hour
Epidural injection1-2.5 %10 minutes
Skin or perineural use in horses and cattle 4-5 %10 minutes
2-Intermediate duration analgesic: -
A-Lignocaine or Lidocaine HCl (Xylocaine® or Debocaine®): -
Advantages: -
1-It is extremely stable solution and can be boiled with acid or alkali         
2-It can be sterilized several times even by autoclaving
3-Its onset is twice faster than procaine
4-It has longer duration of action than procaine (90 min alone and 120 min with epinephrine)
5-It has a sedative effect and the dose of tranquilizer must be reduced
6-It has higher penetration power than procaine and so it is preferred in perineural injection and it is unnecessary to add hyaluronidase to it neither for infiltration nor for nerve blocking purposes
7-It can be used for surface analgesia by intra-synovial injection, for the cornea, or for mucous membranes (4%), particularly those of the throat and larynx, prior to endotracheal intubation
Disadvantages: -
Toxicity by over dose that is expressed by drowsiness, twitching and respiratory depression, and finally convulsions and hypotension ensue. Accordingly the toxic dose is known to be
Animal
Dose in gm
Dose in ml (2%)
Horse and cattle6300 ml 2 %
Dog0.630 ml 2 %
Concentration: -
1-General infiltration (0.5:1 % with no vasoconstrictor)
2-Epidural and nerve block (2% with or without vasoconstrictor)
B-Mepivacaine HCl (Mepacaine®): -
This compound closely resembles lignocaine HCl, and widely used for human dentistry
Advantages: -
1-It is slightly less toxic, even slow intravenous injection over 20 minutes in dog by a dose of 29 mg\ kg, produces convulsion that is followed by sedation
2-It has no vasodilatory effect, making the addition of a vasoconstrictor unnecessary. However, a commercial product with levonordefrin is available in market (Mepacaine-L®).
Concentration: -
For infiltration and nerve block (1-2%) is satisfactory, but generally it is available as ampoules of 1.8 ml of 2 % Mepivacaine HCl with or without levonordefrin.
3-Long duration analgesic: -
A-Tetracaine HCl (Pontocaine®): -
Advantages: -
1-The onset of analgesia is 5-10 minutes                           
2-It is 12 times potent than procaine
3-Its toxicity 10 times that of procaine
4-Lesser interference with corneal healing than other agents, so it is the drug of choice for corneal analgesia
Disadvantages: -
It can't be autoclaved.
Concentration: -
*For the eye (0.2% for 120 min)
*For infiltration and nerve block (0.1%)
B-Bupivacaine HCl (Marcaine®): -
Advantages: -
1-Stable solution on boiling with acid and alkali and shows no change on repeated autoclaving.
2-Represented in different concentrations with or without adrenaline
3-More potent 8 times than procaine and 4 times than lidocaine HCl so it is used as 0.5 % solution         
4-It has greater margin of safety than lignocaine
5-Onset is similar to lignocaine but its effect lasting for 4-6 hours (twice longer period of analgesia), so it is indicated for use in situation where prolonged analgesia is required like relief of pain in equine during acute laminitis
Concentration: -
Aim of use
Concentration
Infiltration 0.25%
Nerve block0.5%
Epidural analgesia0.75%
TYPES OF LOCAL ANALGESIA: -
I-SURFACE ANALGESIA: -
A-Topical analgesia: -
1-Surface analgesia can be produced by freezing of superficial layers of skin by ethyl chloride, ether, or carbonic acid snow, as a result of their rapid volatilization. Their action is superficial and transient, and their use is limited to simple surgical interferences like incision of an abscess. Excessive use may lead to necrosis, and the thawing after their use is very painful.
2-Surface analgesia can be performed by using lignocaine ointment that is applied by skin friction for relief of pruritis
3-Surface analgesia may be performed by using lignocaine 2% aqueous solution topically for relief of superficial abraded or eczematous area
4-Surface analgesia of mucous membrane of the glans penis and vulva can be produced by topical use of lignocaine 2% aqueous solution
5-Surface analgesia of urethral mucous membrane can be adopted by lignocaine 2% gel that works as lubricant and analgesic
6-Surface analgesia of the nasal mucous membrane can be performed by lignocaine 4% spray for trans-nasal passage of stomach tube in dog or for surgical procedures of the nasal chamber in the horse
7-Surface analgesia of the cornea can be performed by topical instillation of 4% lignocaine or 0.2% Tetracaine®
8-Surface analgesia of the joints can be performed by intra-synovial injection of 2 % lignocaine
B-Intrasynovial: -
Surface analgesia is employed for relief of pain arises from pathological conditions of the joint and tendon sheath. The technique involves direct injection of local analgesic into the joint or tendon sheath with mechanical manipulation of the joint or sheath for spreading of the drug, and when the joint or tendon sheath is distended with synovia, it is recommended to aspirate some the fluid to prevent dilution of analgesic. Analgesia usually arises 5-10 minutes after injection and lasts up to 1 hour, as a result of direct effect of the drug on the surface of the joint or sheath.
Uses: -
1-Therapeutic, like relief of pain during arthritis
2-Diagnostic, for diagnosis of arthritis or lameness (therapeutic diagnosis)
II-INFILTRATION ANALGESIA: -
This technique can be used for minor operations or even for major operation either alone or in adjunction with sedation or basal narcosis.
A-Intra-dermal: -
It is a process through which analgesic drug is injected intra-dermal to facilitate injection in animals. The main point of this technique is the humanity as it reduces pain during subsequent procedure of infiltration analgesia.
B-Linear infiltration: -
This method can be performed by creation of insensitive intra-dermal weal through which the needle is inserted subcutaneously into two opposite directions to create analgesic line, and by this method a line of analgesia that has double length of the needle can be created with minimal skin bricking. Usually the drug is injected while the needle is dragged out of the subcutaneous tissue and the amount of required analgesic is 1 ml\ cm2. Although sensation is mainly confined to the skin, but in some circumstances it is recommended to infiltrate the muscular layer beneath the skin as sensory nerves pass through it and this will achieve better analgesia, moreover, involvement of motor nerves that passes through the muscles reduces movement of the muscles during incision. A clear example of this is the linear infiltration of the left flank in cattle that involves both subcutaneous tissue and underlying muscles for induction of rumenotomy or cesarean section. A simultaneous technique is the creation of insensitive weals beside each other in the form of line.
Advantages: -
1-Simple and easy technique
2-It consumes smaller amount of anesthetic and shorter time than inverted-L technique
Disadvantages: -1-Dealyed healing
2-Changes in the anatomical features
3-Consumption of large amount of drug than paravetribral technique
C-Field block analgesia: -
1-Cup shape field block: -
It is an inverted pyramidal shape analgesic area that is created by two punctures, and can be used when the pass of nerve supply is not exactly known. Usually it is applied to an area of bulky musculature.
Advantages: -
1-Absence of anatomical distortion at seat of incision
2-When the drug contains vasoconstrictor, it will produce efficient ischemia
3-Complete muscular relaxation
4-No retardation of healing
2-Inverted-L block: -
It is a field block technique through which only the dorsal and anterior aspects of the flank region are injected subcutaneously with local analgesic solution to produce complete analgesia of the flank for induction of rumenotomy or cesarean. The main point of neglecting the posterior aspect is that the nerves pass to the flank from the dorsal and anterior aspects while is passes caudo-ventrally.
Advantages: -
1-Seat of injection is far from incision line (not interfere with healing)
2-Simple technique and requires no technical skills or complicated equipments
3-It does not cause change of the anatomical features at seat of incision
Disadvantages: -
1-It consumes larger amount of anesthetic than linear infiltration and paravetribral
2-It consumes longer time than linear infiltration
3-Ring block: -
It is a technique used for induction of analgesia by injection of analgesic drug in a ring manner at one level like in teat or digit. On induction of analgesia of the teat, adrenaline shouldn't be incorporated in the injected solution as vasoconstriction may cause necrosis of the compromised teat. The technique is useful for surgical repair of presternal bursitis in buffalo calves, umbilical hernia, amputation of digit etc...
III-INTRAVENOUS REGIONAL ANALGESIA: -
It is a simple technique usually used in dogs and can be performed by injection of 2-3 ml of 1% lignocaine intravenous in the cephalic vein after application of tourniquet on the forearm. Analgesia allover the limb can be achieved and the effect can be reversed just the tourniquet is removed.
IV-LOCAL ANALGESIA OF FRACTURE: -
It is a simple technique performed by injection of 2-5 ml of 1% lignocaine (small animals) or 10-15 ml of 1% lignocaine (large animals) into the hematoma as near as possible to the ends of bone. Analgesia will ensue within 5 minutes after injection.


References: Hall, C.W. and Clarke, K.W. (1983), Veterinary anesthesia, 8th edition; Hall, L.W. (1978), Wrights veterinaray anesthesia and analgesia, 7th edition